Hpv serotypes in head and neck cancer

Hpv high risk serotypes, Difference between papilloma and fibroma

Through the new techniques and establishment of novel protocols, especially in the field of molecular bio­lo­gy, together with the results from in vitro, in vivo pre­cli­ni­cal and clinical studies carried out on an im­pres­sive number of patients with various pathologies, scien­tists have established ample associations between the microbiome composition and certain cancers or the treat­ment response. In some types of cancer, the role of microorganisms has been incriminated, which by their presence can activate certain signaling pathways or produce some metabolites that ultimately affect the cel­lular functioning. Category: DEFAULT Papillomavirus homme dermatologue For some microorganisms such as Fu­so­bac­te­rium nucleatum or toxigenic Bacteroides fragilis in colorectal cancer, the possible mechanisms of action have been already described. Despite this fact, numerous stu­dies are still needed in order to determine whether bac­te­rial presence triggers the neoplastic process or the gut microbial abundance in affected patients is the hpv high risk serotypes of other changes taking place.

Human papilloma virus enfeksiyonu. Inflammatory cell type was determined using specific markers.

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The diagnosis of chronic rhinosinusitis with nasal polyps CRSwNP was made according to current EPOS guidelines based on hpv high risk serotypes history, clinical examination and nasal endoscopy. We examined surgically resected nasal polyps from patients diagnosed with CRSwNP, who benefited from surgical procedures at the Department of Otorhinolaryngology of our institution.

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The polyps were analyzed at the Department of Pathology of our institution utilizing histopathological and immunohistochemical methods as follows: Firstly, the tissues were paraffin­impregnated, sectioned and stained with hematoxylin and eosin. We observed the following histopathological changes: The structure of the epithelium was evidenced by collagenous subjacent stroma with mixed areas, sometimes associated with hyaline zones.

In all types of polyps, we also observed a diffuse underlayer or periglandular lymphoplasmacytic in filtrate composed predominantly from T lymphocytes and eosinophils.

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The histopathological changes suggest the chronic inflammation of the sinus mucosa, which was diffusely distributed in allergic hpv high risk serotypes and with nodular distribution in fibro­inflammatory polyps. The number of B lymphocytes was greater in the fibro­inflammatory polyps.

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On the whole, the findings of this study indicate that the inflammatory infiltrate in nasal polyps from patients with CRSwNP is mainly composed of T cells and eosinophils in all types of polyposis. In addition, a diffuse distribution of allergic polyps and the nodular distribution of fibro­inflammatory polyps, and the hyperplasia of the seromucous glands was observed.

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